Factories of the future will be embedded into a smart grid energy infrastructure, where energy suppliers and consumers are intelligently linked with each other. The smart grid will be characterized by a dynamic matching of energy generation and energy demand using short-term energy storages for buffering. The energy consumption of manufacturing systems must be capable of being adapted to these dynamic requirements of the smart grid. Energy-related objectives like energy-efficiency and energy-flexibility will thus become essential parts of an energy management system for factories. Energy-efficiency can be effectively achieved by the design of manufacturing process chains whereas energy-flexibility can be realized by an appropriate production planning and control. This paper describes a methodology for the design of manufacturing process chains by selecting manufacturing processes and equipment due to energy consumption as well as cost- and flexibility-related objectives. In terms of the production planning and control, a Shop-Floor-Scheduling methodology is presented. The Shop-Floor-Scheduling enables a high level of energy-flexibility by controlling the manufacturing system.