Recent studies focus on the knowledge transfer in industrial clusters with regard to innovation. Research results highlight various factors impacting overall and innovation performances, like for instance the industrial domain, the type of networks and the amount of knowledge generated in a cluster. This paper proposes to examine how clusters are managed, and the impact of the cluster management on the knowledge and innovations in the cluster. To do so, we examine three clusters from different European countries and from the aeronautic field, by analyzing their best practices in term of knowledge generation and sharing as well as innovation. Results tend to show that each cluster undertake specific actions according to its environment, and highlight key innovative initiatives which may be transferred for cluster development purposes.